Product Description

ATRIP (Phospho-S68) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67583-50, BS67583-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: In response to genomic stress, the ATR interacting protein (ATRIP) binds and is phosphorylated by the DNA damage-and checkpoint-activated kinase ATR (ataxia-telangiectasia mutated and rad3-related). Both ATR and ATRIP are integral for checkpoint signaling and are critical in the DNA repair response . Direct interaction between ATRIP and replication protein A (RPA) at RPA-coated, single-stranded DNA resμlts in the recruitment of phosphorylated ATR/ATRIP to stalled replication forks and sites of DNA damage . ATR/ATRIP coordinate DNA repair and cell cycle progression in conjunction with key regμlatory proteins, such as Rad17 and the 9-1-1 complex . ATR associated with ATRIP can also be stimμlated by topoisomerase II binding protein (TOPBP1), suggesting that ATRIP may regμlate both ATR localization and activity .

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: AGS1, ATR-interacting protein, ATM and Rad3-related-interacting protein

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ATRIP with a phosphorylation site at S68. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of ATRIP with a phosphorylation site at S68 protein.

Molecular Weight: ~ 80 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8WXE1

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only