Product Description

B3GL1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18112-50, ES18112-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). The encoded protein of this gene does not use N-acetylglucosamine as an acceptor sugar at all. Multiple transcript variants that are alternatively spliced in the 5' UTR have been described, they all encode the same protein. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human B3GL1 AA range: 24-74

Isotype: IgG

Target: B3GL1

Specificity: This antibody detects endogenous levels of B3GL1 at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Higher expression in heart and brain, and to a lesser extent in lung, placenta, kidney and testis, Lower expression in liver, spleen and stomach, No expression in skeletal muscle,

Molecular Weight (Da): 36kD

Fields: Glycosphingolipid biosynthesis - lacto and neolacto series, Glycosphingolipid biosynthesis - globo and isoglobo series, Metabolic pathways

Function: Catalytic Activity: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide
Cofactor: Magnesium
Function: Transfers N-acetylgalactosamine onto globotriaosylceramide
Online Information: Beta-1,3-galactosyltransferase 3,Online Information: Blood group antigen gene mutation database,Online Information: GlycoGene database,Pathway: Protein modification, protein glycosylation
polymorphism: Different combinations or absence of the P blood group system antigens define 5 different phenotypes: P1, P2, P1(k), P2(k), and P. Genetic variation in B3GALT3 determines the P1(k) and P2(k) phenotype, which is rare and lack the capability to synthesize P antigen identified as globoside
Similarity: Belongs to the glycosyltrans

Subcellular Location: Golgi apparatus membrane, Single-pass type II membrane protein

Storage and Stability: -20°C/1 year

Gene Name: B3GALNT1 B3GALT3 UNQ531/PRO1074

Protein Name: B3GL1

Mouse Gene ID: 26879

Mouse SwissProt Number: Q920V1

Rat Gene ID: 310508

Rat SwissProt Number: Q6AY39

Research Use Only