Product Description

BAGE5 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3791-50, ES3791-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: BAG5, KIAA0873, BAG family molecular chaperone regulator 5, BAG-5, Bcl-2-associated athanogene 5

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from BAGE5. at AA range: 30-110

Isotype: IgG

Target: BAGE5

Specificity: BAGE5 Polyclonal Antibody detects endogenous levels of BAGE5 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain,

Observed Band (KD): 51kD

Function: Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2
Similarity: Contains 4 BAG domains
Subunit: Binds to the ATPase domain of HSP70/HSC chaperones. Binds PARK2

Subcellular Location: nucleus, mitochondrion, cytosol, membrane, inclusion body, perinuclear region of cytoplasm,

Storage and Stability: -20°C/1 year

Gene Name: BAG5

Protein Name: BAG family molecular chaperone regulator 5

Mouse Gene ID: 70369

Mouse SwissProt Number: Q8CI32

Rat Gene ID: 366734

Rat SwissProt Number: Q5QJC9

Research Use Only