Product Description

BAP31 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1748-50, ES1748-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: BCAP31, BAP31, DXS1357E, B-cell receptor-associated protein 31, BCR-associated protein 31, Bap31, 6C6-AG tumor-associated antigen, Protein CDM, p28

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human BAP31. AA range:151-200

Isotype: IgG

Target: BAP31

Specificity: BAP31 Polyclonal Antibody detects endogenous levels of BAP31 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous, Highly expressed in neurons and discrete endocrine cells,

Observed Band (KD): 28kD

Fields: Protein processing in endoplasmic reticulum, Human papillomavirus infection

Function: Disease: Microdeletions in BCAP31 are involved in the contiguous ABCD1/DXS1375E deletion syndrome (CADDS) [MIM: 300475]. Patients manifest profound neonatal hypotonia, subsequent failure to thrive, and cholestatic liver disease
Function: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis
PTM: Cleaved by CASP8 and other caspases
Similarity: Belongs to the BCAP29/BCAP31 family
Subcellular Location: May shuttle between the ER and the intermediate compartment/cis-Golgi complex
Subunit: Homodimer and heterodimer with BCAP29. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II. Interacts with PTPLB
Tissue Specificity: Ubiquitous

Subcellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane, Multi-pass membrane protein May shuttle between the ER and the intermediate compartment/cis-Golgi complex (PubMed:9396746) Associates with the mitochondria-associated endoplasmic reticulum membrane via interaction with TOMM40 (PubMed:31206022)

Storage and Stability: -20°C/1 year

Gene Name: BCAP31

Protein Name: B-cell receptor-associated protein 31

Mouse Gene ID: 27061

Mouse SwissProt Number: Q61335

Research Use Only