Product Description

Beta 2 Microglobμlin Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67043-50, MB67043-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: β2-microglobμlin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecμle, a ternary membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system . As an integral component of the MHC class I complex, β2-microglobμlin plays a critically important role in immune system function . It has important relevance to cancer biology research, for example, research studies have shown that nearly one-third of diffuse large B cell lymphomas contain mutations that inactivate β2-microglobμlin gene function, thereby allowing tumor cells to escape immune detection . In addition, β2-microglobμlin has been identified as an amyloid preprotein with collagen-binding affinity , its accumμlation in osteoarthritic lesions of long-term dialysis patients is reportedly a contributing factor to the condition known as amyloid osteoarthropathy .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: Beta-2-microglobμlin

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Beta 2 Microglobμlin. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of Beta 2 Microglobμlin protein.

Molecular Weight: ~ 12 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P61769

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only