Product Description

BGAT Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18059-50, ES18059-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes proteins related to the first discovered blood group system, ABO. Which allele is present in an individual determines the blood group. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Histo-blood group ABO system transferase (Fucosylglycoprotein 3-alpha-galactosyltransferase) (Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase) (Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase) (EC 2.4.1.40) (Glycoprotein-fucosylgalactoside alpha-galactosyltransferase) (EC 2.4.1.37) (Histo-blood group A transferase) (A transferase) (Histo-blood group B transferase) (B transferase) (NAGAT) [Cleaved into: Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form]

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human BGAT AA range: 222-272

Isotype: IgG

Target: BGAT

Specificity: This antibody detects endogenous levels of BGAT at Human/Mouse

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.47% sodium azide.

Expression: Blood, Human adenocarcinoma, PCR rescued clones, Peripheral, Peripheral blood, Peripheral lymphocytes,

Observed Band (KD): 38kD

Fields: Glycosphingolipid biosynthesis - lacto and neolacto series, Metabolic pathways

Function: Catalytic Activity: UDP-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->2))-D-galactosyl-R
Catalytic Activity: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-(alpha-L-fucosyl-(1->2))-D-galactose
Cofactor: Binds 1 manganese ion per subunit
Domain: The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis
Function: This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individu

Subcellular Location: Golgi apparatus, Golgi stack membrane, Single-pass type II membrane protein Secreted Membrane-bound form in trans cisternae of Golgi Secreted into the body fluid

Storage and Stability: -20°C/1 year

Gene Name: ABO

Protein Name: BGAT

Mouse Gene ID: 80908

Mouse SwissProt Number: P38649

Research Use Only