Product Description

BHE22 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18058-50, ES18058-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. A similar protein in mouse is required for the development of the dorsal cochlear nuclei, and is thought to play a role in in the differentiation of neurons involved in sensory input. The mouse protein also functions in retinogenesis. [provided by RefSeq, Oct 2016],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human BHE22 AA range: 243-293

Isotype: IgG

Target: BHE22

Specificity: This antibody detects endogenous levels of BHE22 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain-specific, with the highest expression in the cerebellum,

Molecular Weight (Da): 42kD

Function: Function: Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA
Similarity: Contains 1 basic helix-loop-helix (bHLH) domain
Tissue Specificity: Brain-specific, with the highest expression in the cerebellum

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: BHLHE22 BHLHB5 TNRC20

Protein Name: BHE22

Mouse Gene ID: 59058

Mouse SwissProt Number: Q8C6A8

Research Use Only