Product Description

BHE40 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES18057-50, ES18057-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human BHE40 AA range: 229-279

Isotype: IgG

Target: BHE40

Specificity: This antibody detects endogenous levels of BHE40 at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach,

Molecular Weight (Da): 45kD

Fields: Circadian rhythm

Function: Function: May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway
PTM: Ubiquitinated, which may lead to proteasomal degradation
Similarity: Contains 1 basic helix-loop-helix (bHLH) domain
Similarity: Contains 1 Orange domain
Subunit: Able to homodimerize or heterodimerize with TCF3/E47. Interacts with ubiquitin-conjugating enzyme UBE2I/UBC9
Tissue Specificity: Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach

Subcellular Location: Cytoplasm Nucleus Predominantly localized in the nucleus (PubMed:11278694)

Storage and Stability: -20°C/1 year

Gene Name: BHLHE40 BHLHB2 DEC1 SHARP2 STRA13

Protein Name: BHE40

Mouse Gene ID: 20893

Mouse SwissProt Number: O35185

Rat Gene ID: 79431

Rat SwissProt Number: O35780

Research Use Only