Biotin Anti-Human CD274/PD-L1 Antibody [29E.2A3] - E-AB-F1133B

Biotin Anti-Human CD274/PD-L1 Antibody [29E.2A3]

Size: 100μg

Catalogue Number: E-AB-F1133B-100

Citations, Manuals and MSDS Available upon request.

Abbreviation: PD-L1

Target Synonym: B7-H1, PD-L1, Programmed cell death ligand 1, B7 homolog 1, B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1,

Conjugation: Biotin

Host: Mouse

Species Reactivity: Human

Application: FCM

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Isotype: Mouse IgG2b, κ

Clone No.: 29E.2A3

UNIProt ID: Q9NZQ7

Background: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

Concentration: 0.5 mg/mL

Control Catalogue Number: E-AB-F09813B

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

GeneID: 29126

Storage: This product can be stored at 2-8°C for 12 months. Do not freeze.

Shipping: Ice bag