Biotin Anti-Mouse CD51 Antibody [RMV-7] - E-AB-F1235B

Biotin Anti-Mouse CD51 Antibody [RMV-7]

Size: 100μg

Catalogue Number: E-AB-F1235B-100

Citations, Manuals and MSDS Available upon request.

Abbreviation: CD51

Target Synonym: Integrin alpha-V, αV integrin, Vitronectin Receptor, Integrin αV chain, ITGAV,

Conjugation: Biotin

Host: Rat

Species Reactivity: Mouse

Application: FCM

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Isotype: Rat IgG1, κ

Clone No.: RMV-7

UNIProt ID: P43406

Background: CD51 is a 140 kD protein, also known as αV?integrin, vitronectin receptor, and integrin αV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins β1, β3, β5?or β6, these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The αvintegrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.

Concentration: 0.5 mg/mL

Control Catalogue Number: E-AB-F09823B

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

GeneID: 16410

Storage: This product can be stored at 2-8°C for 12 months. Do not freeze.

Shipping: Ice bag