Biotin Anti-Mouse IL-17A Antibody [TC11-18H10.1] - E-AB-F1199B

Biotin Anti-Mouse IL-17A Antibody [TC11-18H10.1]

Size: 100μg

Catalogue Number: E-AB-F1199B-100

Citations, Manuals and MSDS Available upon request.

Abbreviation: IL-17A

Target Synonym: Interleukin-17A, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8, CTLA8,

Conjugation: Biotin

Host: Rat

Species Reactivity: Mouse

Application: ICFCM

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Isotype: Rat IgG1, κ

Clone No.: TC11-18H10.1

UNIProt ID: Q62386

Background: IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

Concentration: 0.5 mg/mL

Control Catalogue Number: E-AB-F09823B

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

GeneID: 16171

Storage: This product can be stored at 2-8°C for 12 months. Do not freeze.

Shipping: Ice bag