Product Description

BLMH Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17979-50, ES17979-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution, however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human BLMH AA range: 170-220

Isotype: IgG

Target: BLMH

Specificity: This antibody detects endogenous levels of BLMH at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight (Da): 50kD

Function: Catalytic Activity: Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred
Function: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity
Similarity: Belongs to the peptidase C1 family
Subunit: Homohexamer

Subcellular Location: Cytoplasm Cytoplasmic granule Co-localizes with NUDT12 in the cytoplasmic granules

Storage and Stability: -20°C/1 year

Gene Name: BLMH

Protein Name: BLMH

Mouse Gene ID: 104184

Mouse SwissProt Number: Q8R016

Rat SwissProt Number: P70645

Research Use Only