Product Description

BMAL2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17973-50, ES17973-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human BMAL2 AA range: 495-545

Isotype: IgG

Target: BMAL2

Specificity: This antibody detects endogenous levels of BMAL2 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in fetal brain, Highly expressed in brain and placenta, Lower levels in heart, liver, thymus, kidney and lung, Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN), Also detected in endothelial cells of the heart, lung and kidney, In the brain, specifically expressed in the thalamus, hippocampus and amygdala,

Molecular Weight (Da): 70kD

Function: Function: ARNTL2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription. Also, in umbilical vein endothelial cells, activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1
Induction: Constitutively expressed. Has no circadian rhythm expression pattern
Similarity: Contains 1 basic helix-loop-helix (bHLH) domain
Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
Similarity: Contains 2 PAS (PER-ARNT-SIM) domains
Subunit: Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with CLOCK to form the ARNTL2-CLOCK transactivator. Can form heterodimers or homodimers which interact directly with CLOCK to form the transcription activator. Also interacts with NPAS2 and HIF1A
Tissue Specificity: Expressed in fetal

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: ARNTL2 BHLHE6 BMAL2 CLIF MOP9 PASD9

Protein Name: BMAL2

Mouse Gene ID: 272322

Mouse SwissProt Number: Q2VPD4

Research Use Only