Product Description

BMP-3A Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1777-50, ES1777-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: BMP3, BMP3A, Bone morphogenetic protein 3, BMP-3, Bone morphogenetic protein 3A, BMP-3A, Osteogenin

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human BMP3. AA range:281-330

Isotype: IgG

Target: BMP-3A

Specificity: BMP-3A Polyclonal Antibody detects endogenous levels of BMP-3A protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in adult and fetal cartilage,

Observed Band (KD): 55kD

Fields: Cytokine-cytokine receptor interaction

Function: Function: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification
Induction: Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts
Online Information: Bone morphogenetic protein 3 entry,Similarity: Belongs to the TGF-beta family
Subunit: Homodimer, disulfide-linked
Tissue Specificity: Expressed in adult and fetal cartilage

Subcellular Location: Secreted

Storage and Stability: -20°C/1 year

Gene Name: BMP3

Protein Name: Bone morphogenetic protein 3

Mouse SwissProt Number: Q8BHE5

Research Use Only