Product Description

BMP-8B Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1781-50, ES1781-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: BMP8B, BMP8, Bone morphogenetic protein 8B, BMP-8, BMP-8B, Osteogenic protein 2, OP-2

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human BMP8B. AA range:261-310

Isotype: IgG

Target: BMP-8B

Specificity: BMP-8B Polyclonal Antibody detects endogenous levels of BMP-8B protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Hippocampus, Testis,

Observed Band (KD): 45kD

Fields: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, Thermogenesis

Function: Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis
Online Information: Bone morphogenetic protein 8b entry,Similarity: Belongs to the TGF-beta family
Subunit: Homodimer, disulfide-linked

Subcellular Location: Secreted

Storage and Stability: -20°C/1 year

Gene Name: BMP8B

Protein Name: Bone morphogenetic protein 8B

Mouse SwissProt Number: P55105

Research Use Only