Product Description

Bmx Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1783-50, ES1783-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: BMX, Cytoplasmic tyrosine-protein kinase BMX, Bone marrow tyrosine kinase gene in chromosome X protein, Epithelial and endothelial tyrosine kinase, ETK, NTK38

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human C-ternal ETK. AA range:532-581

Isotype: IgG

Target: ETK

Specificity: Bmx Polyclonal Antibody detects endogenous levels of Bmx protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines,

Observed Band (KD): 78kD

Function: Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Cofactor: Binds 1 zinc ion per subunit
Domain: SH2 domain mediates interaction with RUFY1
Function: Activity is required for interleukin 6 (IL-6) induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells
Induction: Activated by IL-6 through phosphatidylinositol 3-kinase (PI3-kinase) pathway. It is likely that activation occurs through binding of phosphoinositides to the PH domain
Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily
Similarity: Contains 1 Btk-type zinc finger
Similarity: Contains 1 PH domain
Similarity: Contains 1 protein kinase domain
Similarity: Contains 1 SH2 domain
Subunit: Interacts with RUFY1 and RUFY2
tissue sp

Subcellular Location: Cytoplasm Localizes to the edges of spreading cells when complexed with BCAR1

Storage and Stability: -20°C/1 year

Gene Name: BMX

Protein Name: Cytoplasmic tyrosine-protein kinase BMX

Mouse Gene ID: 12169

Mouse SwissProt Number: P97504

Research Use Only