Product Description

BRAC Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES11075-50, ES11075-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from part region of human protein AA range: 181-230

Isotype: IgG

Target: BRAC

Specificity: BRAC Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Detected in testis, but not in other, normal tissues, Detected in lung tumors (at protein level),

Observed Band (KD): 47kD

Function: Disease: Genetic variations in T are associated with susceptibility to neural tube defects (NTD) [MIM: 182940]. NTD are common congenital malformations. Spina bifida, which results from malformations in the caudal region of the neural tube, is compatible with life but associated with significant morbidity, including lower limb paralysis
Function: Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site
Similarity: Contains 1 T-box DNA-binding domain
Subunit: Monomer

Subcellular Location: Nucleus

Storage and Stability: -20°C/1 year

Gene Name: T

Protein Name: Brachyury protein (Protein T)

Mouse SwissProt Number: P20293

Research Use Only