Product Description

BTBD9 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17945-50, ES17945-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This locus encodes a BTB/POZ domain-containing protein. This domain is known to be involved in protein-protein interactions. Polymorphisms at this locus have been reported to be associated with susceptibility to Restless Legs Syndrome and may also be associated with Tourette Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human BTBD9 AA range: 424-474

Isotype: IgG

Target: BTBD9

Specificity: This antibody detects endogenous levels of BTBD9 at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Detected in the brain (at protein level) (PubMed:22658601), Moderately expressed in all specific brain regions examined (PubMed:11572484), Expressed in the dopaminergic neurons of the substantia nigra and A11 neurons (PubMed:22658601), Highly expressed in kidney and moderately expressed in all other adult and fetal tissues (PubMed:11572484),

Molecular Weight (Da): 67kD

Function: Disease: Genetic variations in BTBD9 are associated with susceptibility to restless legs syndrome type 6 (RLS6) [MIM: 611185], also called periodic limb movements in sleep. Restless legs syndrome (RLS) is a neurologic disorder characterized by an uncontrollable urge to move the legs during periods of rest. The majority of patients with RLS also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep
Similarity: Contains 1 BACK (BTB/Kelch associated) domain
Similarity: Contains 1 BTB (POZ) domain
Tissue Specificity: Highly expressed in kidney and moderately expressed in all other adult and fetal tissues. Moderately expressed in all specific brain regions examined

Subcellular Location: cytoplasm, SCF ubiquitin ligase complex,

Storage and Stability: -20°C/1 year

Gene Name: BTBD9 KIAA1880

Protein Name: BTBD9

Mouse Gene ID: 224671

Mouse SwissProt Number: Q8C726

Rat Gene ID: 294318

Rat SwissProt Number: Q5PQR3

Research Use Only