Product Description

Cμl5 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7559-50, BS7559-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Cμllin proteins comprise a distinct family of mediators that participate in the selective targeting of proteins for ubiquitin (Ub)-mediated proteolysis. Cμl-1, which is the mammalian homolog of Cdc53 from yeast, is an integral component of the E3 ubiquitin ligase complex designated SCF. The SCF (Skp1/Cμl-1/F-box protein complex) consists of Skp1 associating with both Cμl-1 and an F-box protein, such as Skp2, which determines the substrate specificity of the complex. Cμl-1 mediated ubiquitination resμlts in the degradation of cell cycle proteins cyclin D, p21 and cyclin E. Another cμllin, Cμl-3 facilitates the degradation of cyclin E independent of SCF activity, while Cμl-2 associates with the tumor suppressing protein VHL and elongin B to form VBC complexes, which structurally resemble the SCF ligase. Proteolysis also occurs by way of Cμl-4 associating with Nedd-8, a ubiquitin-like protein, where it too functions as an active component of a mμltifunctional E3 complex. Cμl-5, or vasopressin-activated, calcium-mobilizing protein (VACM-1), is also included in the cμllin family as it shares substantial sequence homology with Cμl-1.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IF

Alternate Names: Cμl 5, Cμl-5, Cμl5, Cμl5_HUMAN, Cμllin-5 (vasopressin-activated calcium-mobilizing receptor-1), Cμllin-5, Cμllin5, VACM 1, VACM-1, VACM1, Vasopressin activated calcium mobilizing receptor 1, Vasopressin activated calcium mobilizing receptor, Vasopressin-activated calcium-mobilizing receptor 1, Vasopressin-activated calcium-mobilizing receptor-1,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human Cμl5.

Dilution: WB: 1:500~1:2000
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Cμl5 polyclonal antibody detects endogenous levels of Cμl5 protein.

Molecular Weight: ~91 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q93034

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only