Product Description

C32 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES8408-50, ES8408-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: CKLF, CKLF1, HSPC224, Chemokine-like factor, C32

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from Chemokine-like factor at AA range: 103-152

Isotype: IgG

Target: C32

Specificity: C32 Polyclonal Antibody detects endogenous levels of C32 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Isoform 1, isoform 2, isoform 3 and isoform 4 have highest expression levels in adult spleen, lung, testis, ovary, peripheral blood leukocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart, Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate and fetal spleen and liver,

Observed Band (KD): 20kD

Function: Function: Isoform CKLF1 has chemotactic response in rat monocytes, neutrophils, and lymphocytes
Function: May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10
Similarity: Belongs to the chemokine-like factor family
Similarity: Contains 1 MARVEL domain
Tissue Specificity: All 4 isoforms have highest expression levels in adult spleen, lungs, testis, ovary, peripheral blood leucocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate, and fetal spleen and liver

Subcellular Location: [Isoform 1]: Secreted, [Isoform 2]: Membrane, Multi-pass membrane protein, [Isoform 4]: Membrane, Multi-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: CKLF

Protein Name: Chemokine-like factor

Mouse Gene ID: 75458

Mouse SwissProt Number: Q9DAS1

Rat Gene ID: 245978

Rat SwissProt Number: Q9JK79

Research Use Only