Product Description

C9 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1811-50, ES1811-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: C9, Complement component C9

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human C9. AA range:181-230

Isotype: IgG

Target: C9

Specificity: C9 Polyclonal Antibody detects endogenous levels of C9 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Plasma (at protein level),

Observed Band (KD): 70kD

Fields: Complement and coagulation cascades, Prion disease, Amoebiasis, Coronavirus disease - COVID-19, Systemic lupus erythematosus

Function: Disease: Defects in C9 are a cause of component C9 deficiency (C9D) [MIM: 120940]. Patients with C9D suffer from recurrent bacterial infections, predominantly from Neisseria meningitidis
Function: C9 is the final component of the complement system to be added in the assembly of the membrane attack complex. It is able to enter lipid bilayers, forming transmembrane channels
Online Information: C9 mutation db,PTM: Thrombin cleaves factor C9 to produce C9a and C9b
Similarity: Belongs to the complement C6/C7/C8/C9 family
Similarity: Contains 1 EGF-like domain
Similarity: Contains 1 LDL-receptor class A domain
Similarity: Contains 1 MACPF domain
Similarity: Contains 1 TSP type-1 domain

Subcellular Location: Secreted Target cell membrane, Multi-pass membrane protein Secreted as soluble monomer Oligomerizes at target membranes, forming a pre-pore A conformation change then leads to the formation of a 100 Angstrom diameter pore

Storage and Stability: -20°C/1 year

Gene Name: C9

Protein Name: Complement component C9

Mouse SwissProt Number: P06683

Research Use Only