Product Description

CALCOCO2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17885-50, ES17885-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CALCOCO2

Isotype: IgG

Target: CALCOCO2

Specificity: This antibody detects endogenous levels of CALCOCO2 at Human/Mouse/Rat

Dilution: WB 1:500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain,

Observed Band (KD): 53kD

Fields: Mitophagy - animal, Shigellosis, Influenza A

Function: Function: May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion
Miscellaneous: In (PubMed: 7540613) herpes simplex virus-1 infection removed CALCOCO2 from the nucleus, however, remained faintly in areas shown to be domains, containing splicing components. Treatment with IFNB and IFNG showed an increase in number and size of CALCOCO2-specific dots and partial redistribution to the cytoplasm. In (PubMed: 9230084) IFNG increased gene expression only slightly and IFNB did not increase expression
Subcellular Location: In (PubMed: 7540613) localized to nuclear dots. In (PubMed: 9230084/12869526) CALCOCO2 is not a nuclear dot-associated protein but localized predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus
Subunit: Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6. Int

Subcellular Location: Cytoplasm, perinuclear region Cytoplasm, cytoskeleton Cytoplasmic vesicle, autophagosome membrane, Peripheral membrane protein According to PubMed:7540613, localizes to nuclear dots According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot-associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus

Storage and Stability: -20°C/1 year

Gene Name: CALCOCO2 NDP52

Protein Name: CALCOCO2

Mouse Gene ID: 76815

Mouse SwissProt Number: A2A6M5

Research Use Only