Product Description

CALY Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES9139-50, ES9139-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: calcyon neuron specific vesicular protein(CALY) Homo sapiens The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 1-80

Isotype: IgG

Target: CALY

Specificity: CALY Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus, No expression in spleen, Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics,

Observed Band (KD): 23kD

Fields: Dopaminergic synapse

Function: Caution: Was originally (PubMed: 10698743) thought to interact with the D1 dopamine receptor (DRD1) and to play a role in potentiating calcium ion-dependent signaling but this work was later retracted
Function: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis
PTM: Glycosylated
Similarity: Belongs to the NSG family
Subunit: Interacts with CLTA
Tissue Specificity: Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics

Subcellular Location: Cytoplasmic vesicle membrane, Single-pass membrane protein Cell membrane, Single-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: CALY DRD1IP

Protein Name: Neuron-specific vesicular protein calcyon

Mouse SwissProt Number: Q9DCA7

Rat SwissProt Number: P58821

Research Use Only