Product Description

CAR16 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17860-50, ES17860-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CAR16 AA range: 101-151

Isotype: IgG

Target: CAR16

Specificity: This antibody detects endogenous levels of CAR16 at Human

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Widely expressed, Expressed at higher level in placenta, spleen, lymph node and bone marrow, Weakly or not expressed in thymus,

Molecular Weight (Da): 22kD

Fields: NOD-like receptor signaling pathway

Function: Function: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2
Induction: Down-regulated in patients suffering of Huntington disease
Similarity: Contains 1 CARD domain
Subunit: Homooligomer. Interacts with CASP1, CASP4, CARD8 and RIPK2
Tissue Specificity: Widely expressed. Expressed at higher level in placenta, spleen, lymph

Storage and Stability: -20°C/1 year

Gene Name: CARD16 COP COP1

Protein Name: CAR16

Research Use Only