Product Description

CASC3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17854-50, ES17854-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CASC3 AA range: 434-484

Isotype: IgG

Target: CASC3

Specificity: This antibody detects endogenous levels of CASC3 at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Widely expressed, Overexpressed in breast cancers and metastasis, as well as in gastric cancers,

Molecular Weight (Da): 77kD

Fields: Nucleocytoplasmic transport, mRNA surveillance pathway

Function: Domain: The coiled coil domain may be involved in oligomerization
Function: Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport
PTM: Phosphorylated
Subcellular Location: Predominantly found in the perinuclear region (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner
Subunit: Interacts with STAU in an RNA-dependent manner (By similarity). Forms homo-oligomers
Tissue Specificity: Widely expressed. Overexpressed in breast cancers and metastasis, as well as in gastric cancers

Subcellular Location: Cytoplasm Cytoplasm, perinuclear region Nucleus Nucleus speckle Cytoplasm, Stress granule Cytoplasm, Cytoplasmic ribonucleoprotein granule Cell projection, dendrite Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner Transported to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (PubMed:15166247) In nuclear speckles, colocalizes with MAGOH Under stress conditions, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules (PubMed:17652158) In the dendrites of hippocampal neurons, localizes to dendritic ribonucleoprotein granules (By similarity)

Storage and Stability: -20°C/1 year

Gene Name: CASC3 MLN51

Protein Name: CASC3

Mouse Gene ID: 192160

Mouse SwissProt Number: Q8K3W3

Rat Gene ID: 259170

Rat SwissProt Number: Q8K3X0

Research Use Only