Caspase-1 Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA20547-50, RA20547-100
Citations, Manuals and MSDS Available upon request.
Background: caspase 1 (CASP1) Homo sapiens This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012],
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Recommended dilutions: IF: 1:50-200 WB 1:500-2000, IHC 1:50-300, ELISA 1:10000-20000
Alternative Names: caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Applications: IF/ICC; WB; IHC-p; ELISA
Species Cross-Reactivity: Human; Rat
GeneID (Human): 834
Protein MW (KDa): 35
SWISS: P29466
Source: Rabbit
Research Use Only