Caspase 9 Monoclonal Antibody (3-20) - BT-MCA0014

Caspase 9 Monoclonal Antibody (3-20)

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-MCA0014-20, BT-MCA0014-50, BT-MCA0014-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1| this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Research Areas: Cell biology; Cancer; Metabolism

Target Protein: CASP9

Applications: WB, IHC-p, IF, ICC, IP

Reactivity: Human,Mouse,Rat,chicken

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Caspase-9

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 46281

UniProt Accession: Human: P55211

Synonyms: CASP9; MCH6; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6

GeneID: Human: 842

Research Use Only