Product Description

Catenin-δ1  (phospho-Y228)  Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4381-50, BS4381-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Catenin δ-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regμlatory domain containing mμltiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function. Catenin δ-1 fμlfills critical roles in the regμlation of cell-cell adhesion as it regμlates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion. Catenin δ-1 has both positive and negative effects on cadherin-mediated adhesion. Actin dynamics are also regμlated by catenin δ-1, which modμlates RhoA, Rac, and cdc42 proteins. Analogous to β-catenin, catenin δ-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin δ-1 is expressed irregμlarly or is absent in various types of tumor cells, suggesting that catenin δ-1 may function as a tumor suppressor.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Catenin delta-1, Cadherin-associated Src substrate, CAS, p120 catenin, p120(ctn), p120(cas), CTNND1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: Synthetic phosphopeptide derived from human Catenin-δ1 around the phosphorylation site of Tyrosine 228

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Catenin-δ1 (phospho-Y228) polyclonal antibody detects endogenous levels of Catenin-δ1 protein only when phosphorylated at Tyr228.

Molecular Weight: ~ 95,  100 kDa

Pathway: Contribution of ECM and Cytoskeletal Factors to EMT,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O60716

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only