Cation-independent M6PR (IGF2R) Rabbit PolymAb®
Sizes: 20μL, 100μL
Catalogue Numbers: A22421PM-20, A22421PM-100
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611) .
Category: Monoclonal Antibodies
Applications: WB, IF/ICC, IF-P, IHC-P, ELISA
Cross-reactivity: Human, Mouse, Rat
Protein Weight: 274kDa
Observed Molecular Weight: 274kDa
Immunogen: Recombinant protein (or fragment) .
Species: Human
GeneID: 3482
SWISS: P11717
Alternate Names: MPR1; MPRI; CD222; CIMPR; M6P-R; MPR300; CI-M6PR; MPR 300; M6P/IGF2R
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:5000 - 1:20000 IF/ICC, 1:200 - 1:800 IF-P, 1:200 - 1:800 IHC-P, 1:400 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Signal Transduction, Immunology Inflammation, CDs, Cell Intrinsic Innate Immunity Signaling Pathway.
NCBI Alias: IGF2R
Research Use Only