CaVα2δ2 rabbit pAb - ES20792

CaVα2δ2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20792-50, ES20792-100

Citations, Manuals and MSDS Available upon request.

Background: calcium voltage-gated channel auxiliary subunit alpha2delta 2 (CACNA2D2) Homo sapiens Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to

Alternate Name: Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2]

Source: Rabbit

Applications: WB; IHC; IF

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Reactivity: Human; Rat; Mouse

Immunogen: Synthetic Peptide of CaVα2δ2 AA range: 540-620

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 100-120kD

Human Gene ID: 9254

Human SWISS Prot NO: Q9NY47

Subcellular Location: Membrane; Single-pass type I membrane protein. Colocalizes with CACNA1A in lipid raft fractions.

Research Use Only