Product Description

CBX4 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17817-50, ES17817-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CBX4 AA range: 196-246

Isotype: IgG

Target: CBX4

Specificity: This antibody detects endogenous levels of CBX4 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitous,

Molecular Weight (Da): 62kD

Function: Function: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility
Pathway: Protein modification, protein sumoylation
PTM: Phosphorylated on Thr-495 by HIPK2 upon DNA damage, which enhances E3 SUMO-protein ligase activity and promotes sumoylation on Lys-492
Similarity: Contains 1 chromo domain
Subunit: Interacts with histone H3-K9Me3 (By similarity). Component of chromatin-associated class II PcG repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2

Subcellular Location: Nucleus Nucleus speckle Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880) Localized in distinct foci on chromatin (PubMed:18927235)

Storage and Stability: -20°C/1 year

Gene Name: CBX4

Protein Name: CBX4

Mouse Gene ID: 12418

Mouse SwissProt Number: O55187

Research Use Only