Product Description

CCDC6 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17765-50, ES17765-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CCDC6 AA range: 104-154

Isotype: IgG

Target: CCDC6

Specificity: This antibody detects endogenous levels of CCDC6 at Human/Mouse

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Ubiquitously expressed,

Molecular Weight (Da): 52kD

Fields: Pathways in cancer, Thyroid cancer

Function: Disease: A chromosomal aberration involving CCDC6 is a cause of thyroid papillary carcinoma (PACT) [MIM: 188550]. Inversion inv(10)(q11.2, q21) generates the RET/CCDC6 (PTC1) oncogene
Domain: The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation
Subcellular Location: May be a cytoskeletal protein
Tissue Specificity: Ubiquitously expressed

Subcellular Location: Cytoplasm Cytoplasm, cytoskeleton May be a cytoskeletal protein

Storage and Stability: -20°C/1 year

Gene Name: CCDC6 D10S170 TST1

Protein Name: CCDC6

Mouse Gene ID: 76551

Mouse SwissProt Number: D3YZP9

Research Use Only