Product Description

CCL17 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17761-50, ES17761-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: C-C motif chemokine 17 (CC chemokine TARC, Small-inducible cytokine A17, Thymus and activation-regulated chemokine)

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CCL17 AA range: 21-70

Isotype: IgG

Target: CCL17

Specificity: This antibody detects endogenous levels of human CCL17

Dilution: WB 1:500-2000, ELISA(peptide)1:5000-20000

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed at high levels in thymus and at low levels in the lung, colon and small intestine,

Observed Band (KD): 10kD

Fields: Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway

Function: Caution: Was originally (PubMed: 9521068) thought to be a ligand for CCR8
Function: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4
Induction: By phytohemagglutinin (PHA) in the peripheral blood mononuclear cells and by cytokines in monocytes
Online Information: CCL17 entry,Similarity: Belongs to the intercrine beta (chemokine CC) family
Tissue Specificity: Expressed at high levels in thymus and at low levels in the lung, colon and small intestine

Subcellular Location: Secreted

Storage and Stability: -20°C/1 year

Gene Name: CCL17 SCYA17 TARC

Protein Name: CCL17

Research Use Only