Product Description

CCL18 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17760-50, ES17760-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: IHC, ELISA

Alternate Names: C-C motif chemokine 18 (Alternative macrophage activation-associated CC chemokine 1, AMAC-1, CC chemokine PARC, Dendritic cell chemokine 1, DC-CK1, Macrophage inflammatory protein 4, MIP-4, Pulmonary and activation-regulated chemokine, Small-inducible cytokine A18) [Cleaved into: CCL18(1-68), CCL18(3-69), CCL18(4-69)]

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CCL18 AA range: 1-80

Isotype: IgG

Target: CCL18

Specificity: This antibody detects endogenous levels of human CCL18

Dilution: IHC-p 1:50-200, ELISA(peptide)1:5000-20000

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes, Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression, Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid,

Fields: Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway

Function: Function: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses
Induction: Specifically induced in macrophages by IL-4, IL-13, and IL-10. Expression is inhibited by IFN-gamma while glucocorticoids exert a slightly positive synergistic effect in combination with IL-4. Strongly induced in several human cell lines, including monocytic U937 cells, by phorbol myristate acetate (PMA). Induced in PBMC by staphylococcal enterotoxins SEA and SEB
mass spectrometry: PubMed: 11745396,Online Information: CCL18 entry,Similarity: Belongs to the intercrine beta (chemokine CC

Subcellular Location: Secreted

Storage and Stability: -20°C/1 year

Gene Name: CCL18 AMAC1 DCCK1 MIP4 PARC SCYA18

Protein Name: CCL18

Research Use Only