Product Description

CCNB2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES9239-50, ES9239-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human protein. at AA range: 60-140

Isotype: IgG

Target: CCNB2

Specificity: CCNB2 Polyclonal Antibody detects endogenous levels of protein.

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Expression: Brain, Coronary artery, Testis,

Observed Band (KD): 43kD

Fields: FoxO signaling pathway, Cell cycle, Oocyte meiosis, p53 signaling pathway, Cellular senescence, Progesterone-mediated oocyte maturation, Human T-cell leukemia virus 1 infection, Human immunodeficiency virus 1 infection

Function: Developmental Stage: Accumulates steadily during G2 and is abruptly destroyed at mitosis
Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition
Similarity: Belongs to the cyclin family
Similarity: Belongs to the cyclin family. Cyclin AB subfamily
Subunit: Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex

Subcellular Location: nucleus, nucleoplasm, centrosome, cytosol, cell-cell adherens junction, microtubule cytoskeleton, membrane,

Storage and Stability: -20°C/1 year

Gene Name: CCNB2

Protein Name: G2/mitotic-specific cyclin-B2

Mouse SwissProt Number: P30276

Research Use Only