Product Description

CCRL1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1891-50, ES1891-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IF, ELISA

Alternate Names: CCRL1, CCBP2, CCR11, VSHK1, C-C chemokine receptor type 11, C-C CKR-11, CC-CKR-11, CCR-11, CC chemokine receptor-like 1, CCRL1, CCX CKR

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human CCRL1. AA range:291-340

Isotype: IgG

Target: CCRL1

Specificity: CCRL1 Polyclonal Antibody detects endogenous levels of CCRL1 protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Predominantly expressed in heart, Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine,

Observed Band (KD): 40kD

Fields: Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor

Function: Function: Receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25
Similarity: Belongs to the G-protein coupled receptor 1 family
Tissue Specificity: Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine

Subcellular Location: Early endosome Recycling endosome Cell membrane, Multi-pass membrane protein Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane

Storage and Stability: -20°C/1 year

Gene Name: CCRL1

Protein Name: C-C chemokine receptor type 11

Mouse Gene ID: 252837

Mouse SwissProt Number: Q924I3

Research Use Only