Product Description

CD10 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: EA321-50, EA321-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CD10 is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. In neurons, neprilysin is regulated by the protein nicastrin, a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid beta.

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: IHC

Alternate Names: CALLA, Enkephalinase,MME,NEP, Neutral endopeptidase antibody

Clonality: Polyclonal

Immunogen: Recombinant Protein

Isotype: IgG

Dilution: IHC 1:200-500

Concentration: 1mg/mL,

Observed Band (KD): 85kDa

Subcellular Location: Cell membrane

Storage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Research Use Only