Product Description

CD108 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1893-50, ES1893-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: SEMA7A, CD108, SEMAL, Semaphorin-7A, CDw108, JMH blood group antigen, John-Milton-Hargen human blood group Ag, Semaphorin-K1, Sema K1, Semaphorin-L, Sema L, CD antigen CD108

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from CD108. at AA range: 150-230

Isotype: IgG

Target: CD108

Specificity: CD108 Polyclonal Antibody detects endogenous levels of CD108 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level), Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney,

Observed Band (KD): 75kD

Fields: Axon guidance

Function: Function: May play an imortant role in the nervous system and in modulating immune function
Online Information: Blood group antigen gene mutation database,Similarity: Belongs to the semaphorin family
Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
Similarity: Contains 1 PSI domain
Similarity: Contains 1 Sema domain
Tissue Specificity: Expressed in placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney

Subcellular Location: Cell membrane, Lipid-anchor, GPI-anchor, Extracellular side Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes

Storage and Stability: -20°C/1 year

Gene Name: SEMA7A

Protein Name: Semaphorin-7A

Mouse Gene ID: 20361

Mouse SwissProt Number: Q9QUR8

Research Use Only