Product Description

CD137L Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1894-50, ES1894-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided b

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, IF, ELISA

Alternate Names: TNFSF9, Tumor necrosis factor ligand superfamily member 9, 4-1BB ligand, 4-1BBL

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human TNFSF9. AA range:31-80

Isotype: IgG

Target: CD137L

Specificity: CD137L Polyclonal Antibody detects endogenous levels of CD137L protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in brain, placenta, lung, skeletal muscle and kidney,

Observed Band (KD): 23kD

Fields: Cytokine-cytokine receptor interaction

Function: Function: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages
Similarity: Belongs to the tumor necrosis factor family
Subunit: Homotrimer
Tissue Specificity: Expressed in brain, placenta, lung, skeletal muscle and kidney

Subcellular Location: Membrane, Single-pass type II membrane protein

Storage and Stability: -20°C/1 year

Gene Name: TNFSF9

Protein Name: Tumor necrosis factor ligand superfamily member 9

Mouse SwissProt Number: P41274

Research Use Only