Product Description

CD1C Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3968-50, ES3968-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: CD1C, T-cell surface glycoprotein CD1c, CD1c

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human CD1C. AA range:211-260

Isotype: IgG

Target: CD1C

Specificity: CD1C Polyclonal Antibody detects endogenous levels of CD1C protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues,

Observed Band (KD): 37kD

Fields: Tight junction, Hematopoietic cell lineage, Amoebiasis

Function: Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells
Miscellaneous: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface
Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
Subcellular Location: Subject to intracellular trafficking between the cell membrane and endosomes
Subunit: Heterodimer with B2M (beta-2-microglobulin)
Tissue Specificity: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues

Subcellular Location: Cell membrane, Single-pass type I membrane protein Endosome membrane, Single-pass type I membrane protein Lysosome Subject to intracellular trafficking between the cell membrane and endosomes

Storage and Stability: -20°C/1 year

Gene Name: CD1C

Protein Name: T-cell surface glycoprotein CD1c

Research Use Only