Product Description

CD1E Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3970-50, ES3970-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been desc

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: CD1E, T-cell surface glycoprotein CD1e, membrane-associated, hCD1e, R2G1, CD1e

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human CD1E. AA range:321-370

Isotype: IgG

Target: CD1E

Specificity: CD1E Polyclonal Antibody detects endogenous levels of CD1E protein.

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues,

Observed Band (KD): 42kD

Fields: Tight junction, Hematopoietic cell lineage, Amoebiasis

Function: Function: Required for the presentation of glycolipid antigens on the cell surface
PTM: Mono-ubiquitinated
PTM: Proteolytically cleaved in endosomes to yield a soluble form
Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
Subcellular Location: Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells
Subunit: Heterodimer with B2M (beta-2-microglobulin)
Tissue Specificity: Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues

Subcellular Location: [T-cell surface glycoprotein CD1e, membrane-associated]: Golgi apparatus membrane, Single-pass type I membrane protein Early endosome Late endosome Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells, [T-cell surface glycoprotein CD1e, soluble]: Lysosome lumen

Storage and Stability: -20°C/1 year

Gene Name: CD1E

Protein Name: T-cell surface glycoprotein CD1e membrane-associated

Research Use Only