Product Description

CD20 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1901-50, ES1901-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: MS4A1, CD20, B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, CD antigen CD20

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human CD20. AA range:181-230

Isotype: IgG

Target: CD20

Specificity: CD20 Polyclonal Antibody detects endogenous levels of CD20 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed on B-cells,

Observed Band (KD): 33kD

Fields: Hematopoietic cell lineage

Function: Caution: Epitope 1, mapped in PubMed: 16785532, is predicted to be buried in the membrane. Its accessibility to the extracellular space, and thus to antibody recognition, is not explained
Function: This protein may be involved in the regulation of B-cell activation and proliferation
Online Information: CD20 entry,pharmaceutical: Monoclonal antibodies(mAb) against CD20 are used to treat B-cell non-Hodgkin's lymphoma (NHL). These antibodies include Rituximab (Mabthera), Britumomab (Zevalin) and Tositumomab (Bexxar). CD20 engaged by mAb can generate transmembrane signals capable of directly controlling cell growth and triggering cell death in certain tumors. Alternatively, mAb can mediate complement-dependent cytotoxicity
PTM: Phosphorylated. Might be functionally regulated by protein kinase(s)
Similarity: Belongs to the MS4A family
Tissue Specificity: Expressed on B-cells

Subcellular Location: Cell membrane, Multi-pass membrane protein Cell membrane, Lipid-anchor Constitutively associated with membrane rafts

Storage and Stability: -20°C/1 year

Gene Name: MS4A1

Protein Name: B-lymphocyte antigen CD20

Mouse SwissProt Number: P19437

Research Use Only