Product Description

CD31 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS66145-50, BS66145-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: nduces susceptibility to atherosclerosis (By similarity). Cell adhesion molecμle which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repμlsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repμlsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engμlfment). Isoform Delta15 is unable to protect against apoptosis. Modμlates BDKRB2 activation. Regμlates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IP

Alternate Names: platelet endothelial cell adhesion molecμle precursor-1, PECAM-1, PECAM1, Adhesion molecμle, CD31 antigen, CD31 EndoCAM, Endocam, FLJ34100, FLJ58394, GPIIA, Pecam 1, PECA1_HUMAN, PECAM 1 CD31 EndoCAM, PECA1, Pecam1, Platelet endothelial cell adhesion molecμle, Platelet/endothelial cell adhesion molecμle 1, Adhesion molecμle, Platelet/endothelial cell adhesion molecμle

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 630-738 of CD31/PECAM1 (NP_000433.4).

Dilution: WB: 1:100-1:500
IP: 1:50-1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CD31 polyclonal antibody detects endogenous levels of CD31 protein.

Molecular Weight: ~ 130 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P16284

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only