Product Description

CD55 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3980-50, ES3980-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: CD55, CR, DAF, Complement decay-accelerating factor, CD55

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human CD55. AA range:241-290

Isotype: IgG

Target: CD55

Specificity: CD55 Polyclonal Antibody detects endogenous levels of CD55 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins, It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix,

Observed Band (KD): 42kD

Fields: Complement and coagulation cascades, Hematopoietic cell lineage, Viral myocarditis

Function: Domain: The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3
Function: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade
Online Information: Blood group antigen gene mutation database,Online Information: CD55 mutation db,Online Information: Decay-accelerating factor entry,Online Information: Icosahedral capsid structure,polymorphism: Responsible for the Cromer blood group system. It consists of at least

Subcellular Location: [Isoform 1]: Cell membrane, Single-pass type I membrane protein, [Isoform 2]: Cell membrane, Lipid-anchor, GPI-anchor, [Isoform 3]: Secreted, [Isoform 4]: Secreted, [Isoform 5]: Secreted, [Isoform 6]: Cell membrane, Lipid-anchor, GPI-anchor, [Isoform 7]: Cell membrane, Lipid-anchor, GPI-anchor

Storage and Stability: -20°C/1 year

Gene Name: CD55

Protein Name: Complement decay-accelerating factor

Research Use Only