Product Description

CD66e Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3902-50, ES3902-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: CEACAM5, CEA, Carcinoembryonic antigen-related cell adhesion molecule 5, Carcinoembryonic antigen, CEA, Meconium antigen 100, CD66e

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human CEACAM5. AA range:481-530

Isotype: IgG

Target: CEA

Specificity: CD66e Polyclonal Antibody detects endogenous levels of CD66e protein.

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421), Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon,

Observed Band (KD): 76kD

Function: Function: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins
PTM: Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate
Similarity: Belongs to the immunoglobulin superfamily. CEA family
Similarity: Contains 7 Ig-like (immunoglobulin-like) domains
Subunit: Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer
Tissue Specificity: Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon

Subcellular Location: Cell membrane, Lipid-anchor, GPI-anchor Apical cell membrane Cell surface Localized to the apical glycocalyx surface

Storage and Stability: -20°C/1 year

Gene Name: CEACAM5

Protein Name: Carcinoembryonic antigen-related cell adhesion molecule 5

Mouse SwissProt Number: Q3UKK2

Research Use Only