Product Description

CD73 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES3984-50, ES3984-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: NT5E, NT5, NTE, 5'-nucleotidase, 5'-NT, Ecto-5'-nucleotidase, CD73

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human NT5E. AA range:431-480

Isotype: IgG

Target: CD73

Specificity: CD73 Polyclonal Antibody detects endogenous levels of CD73 protein.

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Leukocyte, Liver, Placenta, Skin,

Observed Band (KD): 68kD

Fields: Purine metabolism, Pyrimidine metabolism, Nicotinate and nicotinamide metabolism, Metabolic pathways, Nucleotide metabolism

Function: Catalytic Activity: A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate
Cofactor: Zinc
Disease: There is a decrease in the activity of NT5 in B-cell chronic lymphocytic leukemia
Function: Hydrolyzes extracellular nucleotides into membrane permeable nucleosides
Similarity: Belongs to the 5'-nucleotidase family
Subunit: Homodimer, disulfide-linked

Subcellular Location: Cell membrane, Lipid-anchor, GPI-anchor

Storage and Stability: -20°C/1 year

Gene Name: NT5E

Protein Name: 5'-nucleotidase

Mouse SwissProt Number: Q61503

Research Use Only