Product Description

CD88 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1918-50, ES1918-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: function:Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.,PTM:Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.,similarity:Belongs to the G-protein coupled receptor 1 family.,

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: C5AR1, C5AR, C5R1, C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR, CD antigen CD88

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human N ternal CD88/C5aR. AA range:301-350

Isotype: IgG

Target: CD88

Specificity: CD88 Polyclonal Antibody detects endogenous levels of CD88 protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain,

Observed Band (KD): 45kD

Fields: Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Alcoholic liver disease, Staphylococcus aureus infection, Coronavirus disease - COVID-19

Function: Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production
PTM: Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist
Similarity: Belongs to the G-protein coupled receptor 1 family

Subcellular Location: Cell membrane, Multi-pass membrane protein Cytoplasmic vesicle Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles

Storage and Stability: -20°C/1 year

Gene Name: C5AR1

Protein Name: C5a anaphylatoxin chemotactic receptor

Mouse SwissProt Number: P30993

Research Use Only