Product Description

Cdc23 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1925-50, ES1925-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Monkey

Host: Rabbit

Applications: WB, ELISA

Alternate Names: CDC23, ANAPC8, Cell division cycle protein 23 homolog, Anaphase-promoting complex subunit 8, APC8, Cyclosome subunit 8

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human APC8. AA range:251-300

Isotype: IgG

Target: Cdc23

Specificity: Cdc23 Polyclonal Antibody detects endogenous levels of Cdc23 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Bone marrow, Brain, Duodenum, Epithelium, Pancreas, Placenta,

Observed Band (KD): 69kD

Fields: Cell cycle, Oocyte meiosis, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Human T-cell leukemia virus 1 infection

Function: Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle
Pathway: Protein modification, protein ubiquitination
PTM: Phosphorylated. Phosphorylation on Thr-556 occurs specifically during mitosis
Similarity: Belongs to the APC8/CDC23 family
Similarity: Contains 9 TPR repeats
Subunit: The APC/C is composed of at least 11 subunits

Subcellular Location: intracellular, nucleoplasm, anaphase-promoting complex, cytosol,

Storage and Stability: -20°C/1 year

Gene Name: CDC23

Protein Name: Cell division cycle protein 23 homolog

Mouse Gene ID: 52563

Mouse SwissProt Number: Q8BGZ4

Research Use Only