Product Description

Cdc37 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES1931-50, ES1931-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: CDC37, CDC37A, Hsp90 co-chaperone Cdc37, Hsp90 chaperone protein kinase-targeting subunit, p50Cdc37

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human CDC37. AA range:1-50

Isotype: IgG

Target: Cdc37

Specificity: Cdc37 Polyclonal Antibody detects endogenous levels of Cdc37 protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Lymph, Placenta,

Observed Band (KD): 44kD

Fields: PI3K-Akt signaling pathway

Function: Function: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity
PTM: Constitutively sumoylated by UBE2I
Similarity: Belongs to the CDC37 family
Subunit: Forms a complex with Hsp90. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1

Subcellular Location: Cytoplasm

Storage and Stability: -20°C/1 year

Gene Name: CDC37

Protein Name: Hsp90 co-chaperone Cdc37

Mouse Gene ID: 12539

Mouse SwissProt Number: Q61081

Rat Gene ID: 114562

Rat SwissProt Number: Q63692

Research Use Only