Product Description

CDIPT Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES17559-50, ES17559-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human CDIPT AA range: 128-178

Isotype: IgG

Target: CDIPT

Specificity: This antibody detects endogenous levels of CDIPT at Human/Mouse/Rat

Dilution: WB 1：500-2000

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Detected in placenta (at protein level), Widely expressed, Higher expression in adult liver and skeletal muscle, slightly lower levels seen in pancreas, kidney, lung, placenta, brain, heart, leukocyte, colon, small intestine, ovary, testis, prostate, thymus and spleen, In fetus, expressed in kidney, liver, lung and brain,

Molecular Weight (Da): 23kD

Fields: Inositol phosphate metabolism, Glycerophospholipid metabolism, Metabolic pathways, Phosphatidylinositol signaling system

Function: Catalytic Activity: CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol
Cofactor: Magnesium
Cofactor: Manganese
Function: Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns: inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme
Induction: Inhibited by PtdIns (product inhibition), phosphatidylinositol phosphate, and nucleoside di- and tri-phosphates
Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tissue Specificity: Widely expressed. Higher expression in adult liver and skeletal muscle, slightly lower levels seen in pancreas, kidney, lung, placenta, brain, heart, leukocyte, colon, small intestine, ovary, testis, prostate, thymus and spleen. In fetus,

Subcellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein Cell membrane, Multi-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: CDIPT PIS PIS1

Protein Name: CDIPT

Mouse Gene ID: 52858

Mouse SwissProt Number: Q8VDP6

Rat Gene ID: 192260

Rat SwissProt Number: P70500

Research Use Only